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Method of administration: Intra-articular.
Dose and administration: Hyruan ONE is a single injection, single dose preparation and should only be injected once per treatment course. The recommended dose is 3 mL for knee joint. Hyruan ONE should be administered by a medical professional.
Geriatrics: Since physiological function of geriatrics has a declining tendency, administration should be made carefully. Although the number of geriatrics over the age of 65 treat with Hyruan ONE is not sufficient as 18.5% (53/287), difference in the reaction incidence rate after administration of Hyruan ONE between geriatrics and non-geriatric group was not observed in the clinical trial.
